Protein Modification Reagents
![eMolecules Methyltetrazine-PEG4-STP Ester | Broadpharm |686.560 | C26H27F4N4NaO10S | 0.000 | [Na+].Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCC(=O)Oc2c(F)c(F)c(c(F)c2F)S([O-])(=O)=O)cc1 | 10mg | 795362051](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472604.JPG-250.jpg)
eMolecules Methyltetrazine-PEG4-STP Ester | Broadpharm |686.560 | C26H27F4N4NaO10S | 0.000 | [Na+].Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCC(=O)Oc2c(F)c(F)c(c(F)c2F)S([O-])(=O)=O)cc1 | 10mg | 795362051
Methyltetrazine-PEG4-STP Ester | Broadpharm |686.560 | C26H27F4N4NaO10S | 0.000 | [Na+].Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCC(=O)Oc2c(F)c(F)c(c(F)c2F)S([O-])(=O)=O)cc1 | 10mg | 795362051
Medchemexpress LLC BCN-endo-PEG4-NHS 25mg
BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN which allows for further synthesis of macrocyclic complexes In click chemistry endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts
Medchemexpress LLC Pc biotin-peg3-nhs ester | 2353409-93-3 | 95.0% | 840.89 g/mol | C36H52N6O15S | 5 MG
PC Biotin-PEG3-NHS ester is a cleavable three-unit polyethylene glycol (PEG3) linker bearing a biotin tag and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines, used in linker and biotinylation chemistries.
- Cleavable PEG3 linker suitable for conjugation chemistries.
- Contains an NHS ester for efficient reaction with primary amines.
- Biotin tag enables affinity capture and detection.
- Supplied in small, research-scale quantities for synthetic workflows.
- Stable when stored as recommended; purity suitable for research use.
Cayman Chemical Boc-NH-PEG3-CH2CoH 100mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
Medchemexpress LLC Mal-PEG4-PFP ester | 1415800-42-8 | MFCD28556926 | >98.0% | 511.39 g/mol | C21H22F5NO8 | 100 MG
Mal-PEG4-PFP ester is a non-cleavable antibody-drug conjugate (ADC) linker containing a maleimide thiol-reactive group, a four-unit polyethylene glycol (PEG4) spacer, and a pentafluorophenyl (PFP) activated ester for bioconjugation. It is supplied as a solid for research use.
- Non-cleavable maleimide PEG4 linker
- PFP ester for activated carboxyl conjugation
- Suitable for ADC and bioconjugation workflows
- Solid powder form, typically supplied at 100 mg
- Intended for research use only
Medchemexpress LLC Dbco-NHCO-PEG4-NH-Boc | 1255942-12-1 | MFCD30730371 | 98.0% | 623.74 g/mol | C34H45N3O8 | 50 MG
DBCO-NHCO-PEG4-NH-Boc is a DBCO-containing PEG4-based linker and click chemistry reagent used for strain-promoted alkyne-azide cycloaddition (SPAAC). It is commonly applied in antibody-drug conjugate assembly, PROTAC construction, and site-specific bioconjugation. The molecule contains a Boc-protected amine and a PEG4 spacer to improve solubility and flexibility.
- enables copper-free SPAAC bioconjugation
- contains a PEG4 spacer for improved solubility
- features a Boc-protected amine for orthogonal deprotection
- suitable for ADC and PROTAC linker synthesis
- provided as a small-scale reagent for research use
Medchemexpress LLC 5,8-dioxa-2,11-diazatetradecanoic acid 14-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl) methyl ester | 2675364-08-4 | 98.1% | 475.53 | C24H33N3O7 | 10 MG
BCN-endo-PEG2-maleimide is an ADC linker that combines an endo-bicyclononyne (BCN) reactive group, a PEG2 spacer, and a maleimide thiol-reactive moiety for use in click chemistry and thiol conjugation workflows.
- High purity suitable for conjugation (98.1%).
- Provides a BCN moiety for strain-promoted azide-alkyne cycloaddition.
- Maleimide group enables selective thiol coupling.
- PEG2 spacer improves aqueous solubility and reduces steric hindrance.
- Molecular weight 475.53 g/mol; formula C24H33N3O7.
- Available in small research quantities (for example, 10 mg).
Sigma Aldrich Fine Chemicals Biosciences DL-Dithiothreitol suitable for electrophoresis, >=99% | 3483-12-3 | MFCD00004877 | 5G
DL-Dithiothreitol suitable for electrophoresis, >=99% | Purity: >=99% | Mol Wt: 154.25 | 3483-12-3 | MFCD00004877 | 5G
Medchemexpress LLC WDR5 degrader-1 | 3032434-45-7 | 98.00% | 972.98 | 5 MG
WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. It selectively degrades WDR5 over the CRBN neo-substrate IKZF1.
- Cereblon (CRBN)-recruiting degrader
- Selectively degrades WDR5 over IKZF1
Medchemexpress LLC PROTAC EGFR degrader 3 | 2768472-28-0 | 97.4% | C60H77N13O5S | 1 MG
PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. It exhibits excellent cellular activity against H1975 and HCC827 cells with high selectivity. Research indicates that the lysosome is involved in the degradation process of EGFR mutant degradation. This product is intended for research use only and not for sale to patients.
- Potent PROTAC EGFR degrader
- Excellent cellular activity against H1975 and HCC827 cells
- High selectivity
- Lysosome involved in EGFR mutant degradation process
- For research use only
Medchemexpress LLC 3031336-58-7 | 95.6% | 1151.78 | C58H72ClFN12O8S | 5 MG
PROTAC EGFR degrader 2 is a PROTAC designed to selectively degrade the epidermal growth factor receptor (EGFR) and to support biochemical and cellular research into EGFR-driven signaling and antiproliferative effects.
- Potent EGFR degrader with reported DC50 36.51 nM.
- Exhibits antiproliferative activity (IC50 ≈4.0 nM).
- Purity 95.6% suitable for research applications.
- DMSO solubility up to 100 mg/mL; ultrasonic assistance recommended.
- Supplied as a light yellow to yellow solid for handling convenience.
- Store solid at 4°C protected from light; in solution store at -80°C (6 months) or -20°C (1 month).