Protein Modification Reagents
Medchemexpress LLC Dspe-peg5000-mal ammonium | 474922-22-0 | 98.4% | (C2H4O)nC51H92N1O13P.H3N | 25 MG
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents. DSPE-PEG5000-Mal ammonium contains PEG5000.
- Contains DSPE phospholipid and maleimide for nanostructured lipid carrier preparation
- Extends blood circulation time
- Provides higher stability for encapsulated agents
- Contains PEG5000
Medchemexpress LLC Biotin-PEG4-NHS ester | 459426-22-3 | 99.6% | C25H40N4O10S | 5 G
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are compounds with two distinct ligands joined by a linker. One ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- Biotin-labeled, PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
- High purity of 99.6%
- Solid appearance, white to off-white color
- Stable under recommended storage conditions
Medchemexpress LLC Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane | 1421933-29-0 | 97.0% | C36H66N4O14 | 50 MG
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PROTAC linker
- Click chemistry reagent
- Contains an azide group for CuAAc reaction
- Can undergo SPAAC reactions with DBCO or BCN groups
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Cy5-PEG5-azide bromide | 98.8% | C44H63BrN6O6 | 2 MG
Cy5-PEG5-azide is a PEG-based linker utilized in the synthesis of PROTACs, which are compounds designed to selectively degrade target proteins. This reagent facilitates click chemistry reactions, containing an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, or strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Enables targeted protein degradation.
- Supports efficient synthesis of degraders.
- Compatible with multiple click chemistry methods.
- Offers a versatile conjugation tool for research.
- High purity for reliable experimental results.
Medchemexpress LLC M-PEG12-DBCO | 96.9% | C44H66N2O14 | 50 MG
m-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC t-Boc-Aminooxy-PEG4-NHS ester | 2401831-99-8 | 99.9% | C20H34N2O11 | 50 MG
t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC M-PEG12-DBCO | 96.9% | C44H66N2O14 | 100 MG
m-PEG12-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs utilizing this linker connect an E3 ubiquitin ligase ligand with a target protein ligand to leverage the intracellular ubiquitin-proteasome system for selective target protein degradation.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Facilitates selective degradation of target proteins
Medchemexpress LLC DSPE-PEG2000-Maleimide | 99.6% | 50 MG
DSPE-PEG2000-Maleimide is a phospholipid-PEG conjugate. It utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. This product covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, which provides targeting capabilities to the particles. It can be used in research related to breast cancer, lymphoma, and inherited retinal degeneration.
- Used to prepare targeted liposomes (TLPD).
Medchemexpress LLC PEG-bis-amine (MW 20000) | 24991-53-5 | 98.0% | (C2H4O)nC4H12N2O | 100 MG
PEG-bis-amine (MW 20000) is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC DSPE-PEG-FITC | 1000788-53-3 | 10,000 (average) | 50 MG
DSPE-PEG-FITC (MW 10000) is a fluorescent lipid-PEG conjugate composed of a DSPE lipid anchor linked to a polyethylene glycol (PEG) chain terminated with fluorescein isothiocyanate (FITC). Supplied as a yellow-orange solid, it is used to introduce fluorescent labeling and PEGylation into liposomes, lipid nanoparticles, and other lipid-based formulations for imaging, tracking, and formulation development.
- Provides fluorescent labeling for liposomes and lipid nanoparticles.
- Adds PEGylation to improve circulation and reduce nonspecific interactions.
- Suitable for in vitro and in vivo imaging and tracking applications.
- Available in multiple package sizes including 50 mg.
- Yellow to orange solid; soluble in DMSO with sonication and warming.
- Batch-specific certificate of analysis available for analytical data.
Medchemexpress LLC Biotin-PEG2-C6-azide 25mg | 1011268-29-3 | 513.7 g/mol | C22H39N7O5S | 25 MG
Biotin-PEG2-C6-azide is a PEG-based linker that combines a biotin affinity tag with a terminal azide group for Cu(I)-catalyzed azide-alkyne cycloaddition (click chemistry). It is intended for laboratory research use in bioconjugation, affinity capture, immobilization, and PROTAC construction.
- Contains a terminal azide for copper-catalyzed click chemistry.
- Includes biotin for streptavidin/avidin affinity capture.
- PEG2 spacer improves solubility and provides flexible linkage.
- Suitable for bioconjugation and PROTAC linker synthesis.
- Supplied as a solid for research use only.
Medchemexpress LLC m-PEG-DSPE sodium (MW 3000) | 95.0% | 3,000 Da | 50 MG
m-PEG-DSPE sodium (MW 3000) is a methoxy-polyethylene glycol-conjugated distearoylphosphatidylethanolamine sodium salt intended for research use in drug delivery and nanoparticle or liposome surface modification. It is a PEGylated lipid (PEG average MW 3000) provided as a purified polymeric lipid material suitable for formulation and surface-stabilization applications.
- Provides PEGylation for improved circulation and reduced opsonization.
- Average PEG molecular weight 3,000 Da for steric stabilization.
- Sodium salt form for aqueous compatibility.
- Purity approximately 95.0%.
- Suitable for nanoparticle, liposome, and formulation research.
- Available in small laboratory quantities such as 50 mg and larger sizes by request.
- Store sealed away from moisture; in solvent: -80°C (6 months) or -20°C (1 month).
eMolecules Fmoc-NH-PEG12-CH2COOH | 675606-79-8 | MFCD30723256 | 1g
Broadpharm | Fmoc-NH-PEG12-CH2COOH | 1g | 340377161 | BP-23536 | 95.000 | 675606-79-8 | MFCD30723256 | 825.946 | C41H63NO16
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Medchemexpress LLC Aminooxy-amido-PEG4-propargyl | 2253965-03-4 | 97.0% | 304.34 g/mol | C13H24N2O6 | 250 MG
Aminooxy-amido-PEG4-propargyl is a viscous, colorless to light yellow PEG-based ADC linker containing an alkyne (propargyl) functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is used as a click chemistry reagent for bioconjugation and antibody-drug conjugate synthesis and is supplied at laboratory research scales.
- Non-cleavable 4-unit PEG linker.
- Contains alkyne handle for CuAAC click reactions.
- Suitable for bioconjugation and ADC synthesis.
- High purity (~97.0%) for research use.
- Available in small-scale laboratory quantities.
![Medchemexpress LLC 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate | 130955-37-2 | MFCD30723269 | >95.0% | 286.34 g/mol | C10H22O7S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203493.png-250.jpg)
Medchemexpress LLC 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate | 130955-37-2 | MFCD30723269 | >95.0% | 286.34 g/mol | C10H22O7S | 50 MG
m-PEG4-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs m-PEG4-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]